SCF-RDOS INDICATION REGISTRY | Neuroscience Disease, Disorder & Condition Master Registry

Registry Code: SCF-RDOS-NEURO-0001

Domain: Neuroscience, Neurology, Neuropsychiatry, Neuroimmunology, Neurovascular Medicine, Neurodegeneration, Neurodevelopment, Neurogenetics, Neurotrauma, Neuroendocrinology

This registry is organized according to disease-class architecture to support:

• SCF Encyclopedia Development
• SCF Pathogenesis Mapping
• SCF Viragenesis Analysis
• SCF API Discovery Programs
• Clinical Research Programs
• Translational Development Pipelines
• FDA-Aligned Indication Portfolio Planning

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I. NEURODEGENERATIVE DISEASES

Alzheimer’s Spectrum

• Alzheimer’s Disease
• Early-Onset Alzheimer’s Disease
• Familial Alzheimer’s Disease
• Posterior Cortical Atrophy
• Logopenic Primary Progressive Aphasia

Parkinsonian Disorders

• Parkinson’s Disease
• Young-Onset Parkinson’s Disease
• Familial Parkinson’s Disease
• Parkinson’s Disease Dementia

Lewy Body Disorders

• Dementia with Lewy Bodies
• Diffuse Lewy Body Disease

Tauopathies

• Progressive Supranuclear Palsy
• Corticobasal Degeneration
• Pick’s Disease
• Frontotemporal Dementia
• Frontotemporal Lobar Degeneration

Motor Neuron Disorders

• Amyotrophic Lateral Sclerosis (ALS)
• Primary Lateral Sclerosis
• Progressive Muscular Atrophy
• Kennedy Disease
• Spinal Muscular Atrophy

Polyglutamine Disorders

• Huntington’s Disease
• Dentatorubral-Pallidoluysian Atrophy
• Spinocerebellar Ataxias

Prion Diseases

• Creutzfeldt-Jakob Disease
• Variant Creutzfeldt-Jakob Disease
• Fatal Familial Insomnia
• Gerstmann-Sträussler-Scheinker Syndrome
• Kuru

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II. DEMYELINATING & NEUROIMMUNOLOGICAL DISEASES

Multiple Sclerosis Spectrum

• Relapsing-Remitting Multiple Sclerosis
• Secondary Progressive Multiple Sclerosis
• Primary Progressive Multiple Sclerosis
• Clinically Isolated Syndrome
• Radiologically Isolated Syndrome

Autoimmune Demyelinating Disorders

• Neuromyelitis Optica Spectrum Disorder
• MOG Antibody Disease
• Acute Disseminated Encephalomyelitis

Autoimmune Encephalitides

• Anti-NMDA Receptor Encephalitis
• LGI1 Encephalitis
• CASPR2 Encephalitis
• GABA Receptor Encephalitis
• Autoimmune Limbic Encephalitis

Peripheral Neuroimmune Disorders

• Guillain-Barré Syndrome
• Chronic Inflammatory Demyelinating Polyneuropathy
• Multifocal Motor Neuropathy
• Vasculitic Neuropathy

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III. CEREBROVASCULAR DISEASES

Ischemic Disorders

• Ischemic Stroke
• Lacunar Stroke
• Embolic Stroke
• Cryptogenic Stroke
• Transient Ischemic Attack

Hemorrhagic Disorders

• Intracerebral Hemorrhage
• Subarachnoid Hemorrhage
• Intraventricular Hemorrhage
• Cerebellar Hemorrhage
• Brainstem Hemorrhage

Cerebrovascular Structural Disorders

• Cerebral Aneurysm
• Arteriovenous Malformation
• Cavernous Malformation
• Dural Arteriovenous Fistula
• Moyamoya Disease

Venous Disorders

• Cerebral Venous Sinus Thrombosis
• Cortical Vein Thrombosis

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IV. EPILEPSY & SEIZURE DISORDERS

Generalized Epilepsies

• Juvenile Myoclonic Epilepsy
• Childhood Absence Epilepsy
• Generalized Tonic-Clonic Epilepsy

Focal Epilepsies

• Temporal Lobe Epilepsy
• Frontal Lobe Epilepsy
• Occipital Lobe Epilepsy
• Parietal Lobe Epilepsy

Severe Epileptic Syndromes

• Dravet Syndrome
• Lennox-Gastaut Syndrome
• West Syndrome
• Rasmussen Encephalitis

Seizure Conditions

• Status Epilepticus
• Febrile Seizures
• Reflex Epilepsy

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V. NEURODEVELOPMENTAL DISORDERS

Autism Spectrum Disorders

• Autism Spectrum Disorder
• Asperger Syndrome (historical classification)
• Rett Syndrome
• Childhood Disintegrative Disorder

Intellectual Development Disorders

• Intellectual Disability
• Global Developmental Delay

ADHD Spectrum

• Attention Deficit Hyperactivity Disorder
• Attention Deficit Disorder

Communication Disorders

• Developmental Language Disorder
• Speech Sound Disorder
• Childhood Apraxia of Speech

Learning Disorders

• Dyslexia
• Dyscalculia
• Dysgraphia

Motor Development Disorders

• Developmental Coordination Disorder
• Tic Disorders

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VI. MOVEMENT DISORDERS

Hyperkinetic Disorders

• Essential Tremor
• Dystonia
• Chorea
• Ballismus
• Athetosis
• Myoclonus

Tic Disorders

• Tourette Syndrome
• Persistent Motor Tic Disorder
• Persistent Vocal Tic Disorder

Hypokinetic Disorders

• Parkinsonism
• Drug-Induced Parkinsonism
• Vascular Parkinsonism

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VII. NEUROMUSCULAR DISEASES

Motor Neuron Disorders

• ALS
• SMA
• Progressive Muscular Atrophy

Neuromuscular Junction Disorders

• Myasthenia Gravis
• Lambert-Eaton Myasthenic Syndrome
• Congenital Myasthenic Syndromes

Muscular Dystrophies

• Duchenne Muscular Dystrophy
• Becker Muscular Dystrophy
• Limb-Girdle Muscular Dystrophy
• Facioscapulohumeral Dystrophy
• Emery-Dreifuss Muscular Dystrophy

Myopathies

• Inflammatory Myopathy
• Dermatomyositis
• Polymyositis
• Inclusion Body Myositis
• Mitochondrial Myopathy
• Metabolic Myopathy

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VIII. PERIPHERAL NERVOUS SYSTEM DISORDERS

Neuropathies

• Diabetic Neuropathy
• Small Fiber Neuropathy
• Hereditary Neuropathy
• Toxic Neuropathy
• Chemotherapy-Induced Neuropathy

Compression Neuropathies

• Carpal Tunnel Syndrome
• Cubital Tunnel Syndrome
• Radial Neuropathy
• Tarsal Tunnel Syndrome

Plexopathies

• Brachial Plexopathy
• Lumbosacral Plexopathy

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IX. HEADACHE DISORDERS

Primary Headaches

• Migraine
• Migraine with Aura
• Chronic Migraine
• Hemiplegic Migraine
• Cluster Headache
• Tension-Type Headache
• Trigeminal Autonomic Cephalalgias

Secondary Headaches

• Post-Traumatic Headache
• Medication Overuse Headache
• Intracranial Hypertension Headache

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X. SLEEP & CIRCADIAN DISORDERS

Sleep Disorders

• Insomnia Disorder
• Hypersomnia
• Narcolepsy Type 1
• Narcolepsy Type 2

Sleep-Related Breathing Disorders

• Obstructive Sleep Apnea
• Central Sleep Apnea

Circadian Disorders

• Delayed Sleep Phase Disorder
• Advanced Sleep Phase Disorder
• Non-24-Hour Sleep-Wake Disorder
• Shift Work Disorder

Parasomnias

• REM Sleep Behavior Disorder
• Sleepwalking
• Sleep Terrors

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XI. TRAUMATIC & ACQUIRED BRAIN INJURIES

Brain Injury

• Mild Traumatic Brain Injury
• Moderate Traumatic Brain Injury
• Severe Traumatic Brain Injury
• Concussion
• Repetitive Head Injury

Chronic Neurotrauma

• Chronic Traumatic Encephalopathy
• Post-Concussion Syndrome

Spinal Trauma

• Acute Spinal Cord Injury
• Chronic Spinal Cord Injury

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XII. NEUROGENETIC DISORDERS

Channelopathies

• Dravet Syndrome
• Episodic Ataxia
• Familial Hemiplegic Migraine

Leukodystrophies

• Adrenoleukodystrophy
• Metachromatic Leukodystrophy
• Krabbe Disease
• Canavan Disease
• Pelizaeus-Merzbacher Disease

Lysosomal Storage Disorders

• Tay-Sachs Disease
• Niemann-Pick Disease
• Gaucher Disease Type II/III
• Batten Disease

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XIII. CEREBELLAR & ATAXIA DISORDERS

• Friedreich Ataxia
• Spinocerebellar Ataxias
• Episodic Ataxias
• Cerebellar Degeneration
• Multiple System Atrophy-Cerebellar Type

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XIV. NEUROENDOCRINE & HYPOTHALAMIC DISORDERS

• Hypothalamic Dysfunction
• Kallmann Syndrome
• Central Diabetes Insipidus
• Pituitary Apoplexy
• Hypopituitarism with Neurological Manifestations

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XV. NEURO-ONCOLOGY

Primary Brain Tumors

• Glioblastoma
• Astrocytoma
• Oligodendroglioma
• Ependymoma
• Medulloblastoma

Meningeal Tumors

• Meningioma

Cranial Nerve Tumors

• Vestibular Schwannoma

Pituitary Tumors

• Pituitary Adenoma
• Pituitary Carcinoma

Secondary Tumors

• Brain Metastases
• Leptomeningeal Carcinomatosis

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XVI. NEUROINFECTIOUS DISEASES

Viral

• Viral Encephalitis
• Herpes Simplex Encephalitis
• West Nile Encephalitis
• Japanese Encephalitis
• HIV-Associated Neurocognitive Disorder
• Progressive Multifocal Leukoencephalopathy

Bacterial

• Bacterial Meningitis
• Neurotuberculosis
• Neurosyphilis
• Brain Abscess

Fungal

• Cryptococcal Meningitis
• Cerebral Aspergillosis

Parasitic

• Neurocysticercosis
• Cerebral Malaria
• Toxoplasmosis

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XVII. NEUROPSYCHIATRIC & BRAIN-BASED DISORDERS

Psychotic Disorders

• Schizophrenia
• Schizoaffective Disorder

Mood Disorders

• Major Depressive Disorder
• Bipolar I Disorder
• Bipolar II Disorder

Anxiety Disorders

• Generalized Anxiety Disorder
• Panic Disorder
• Social Anxiety Disorder

Obsessive-Compulsive Disorders

• Obsessive-Compulsive Disorder
• Body Dysmorphic Disorder

Trauma Disorders

• Post-Traumatic Stress Disorder
• Complex PTSD

Dissociative Disorders

• Dissociative Identity Disorder
• Depersonalization Disorder

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XVIII. PAIN & SENSORY NEUROSCIENCE DISORDERS

Neuropathic Pain

• Trigeminal Neuralgia
• Postherpetic Neuralgia
• Complex Regional Pain Syndrome
• Phantom Limb Pain

Central Pain Disorders

• Central Post-Stroke Pain
• Thalamic Pain Syndrome

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XIX. AUTONOMIC NERVOUS SYSTEM DISORDERS

• Postural Orthostatic Tachycardia Syndrome (POTS)
• Pure Autonomic Failure
• Multiple System Atrophy
• Autoimmune Autonomic Ganglionopathy
• Neurogenic Orthostatic Hypotension

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XX. FUNCTIONAL NEUROLOGICAL DISORDERS

• Functional Neurological Disorder
• Psychogenic Non-Epileptic Seizures
• Functional Movement Disorder
• Functional Cognitive Disorder

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SCF-RDOS NEUROSCIENCE REGISTRY SUMMARY

Major Registry Domains: 20

Approximate Distinct Indications: 250–350+

SCF Module Alignment:

• Neurodegenerative
• Neurovascular
• Neuroimmune
• Neurodevelopmental
• Neurogenetic
• Neuroendocrine
• Neurooncology
• Neuroinfectious
• Neuropsychiatric
• Neurotrauma
• Autonomic Neuroscience
• Connectomics Disorders
• Neuroenergetic Disorders
• Sensory Neuroscience Disorders

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MASTER REGISTRY INDEX

SCF-RDOS-NEURO-0001 — Neuroscience Indication Registry

SCF-ENC-ADAPT-0001 — SCF Encyclopedia Adaptive Master Template

SCF-PATH-EXT-0001 — SCF Pathophysiology Protocol Extended Version

SCF-SCP-0001 — Synergistic Compatibility Principles

SCF-CRP-0001 — SCF Clinical Research Project Outline

SCF-CRD-WORKFLOW-0001 — SCF Clinical Research & Development Workflow