Encephalopathy Connectomic Collapse Atlas (ECCA-PRION) | Prion Encephalopathy Acupuncture Point Mapping Atlas

SCF-ECCA-PRION-ACU-0010

Prion Encephalopathy Acupuncture Point Mapping Atlas

SCF Neural Mapping Schema

Rapid Neurodegenerative Connectomic Collapse System

Encephalopathy Connectomic Collapse Atlas (ECCA-PRION)

Clinical Positioning

Prion diseases are rapidly progressive fatal neurodegenerative disorders characterized by widespread neuronal loss, astrocytosis, synaptic destruction, thalamocortical collapse, autonomic dysfunction, sleep architecture failure, cerebellar degeneration, and global connectomic disintegration.

This atlas is intended solely as a neuroconnectomic mapping framework for supportive neuromodulation research and symptom management.

No evidence currently demonstrates disease-modifying effects of acupuncture in prion disease.

I. SCF PRION CONNECTOMIC COLLAPSE NETWORK

Primary Failure Axes

Axis 1

Prion Propagation Network

PrPSc Accumulation

→ Synaptic Failure

→ Cortical Degeneration

→ Cognitive Collapse

Axis 2

Thalamocortical Failure Network

Thalamic Degeneration

→ Sleep Architecture Loss

→ Autonomic Dysregulation

→ Consciousness Disturbance

Axis 3

Brainstem Failure Network

Dorsal Vagal Complex Injury

→ Cardiovagal Dysfunction

→ Respiratory Instability

→ Autonomic Collapse

Axis 4

Cerebellar Degeneration Network

Purkinje Cell Loss

→ Ataxia

→ Gait Dysfunction

→ Motor Coordination Failure

Axis 5

Limbic Collapse Network

Amygdala-Hippocampal Degeneration

→ Behavioral Dysfunction

→ Emotional Dysregulation

→ Neuropsychiatric Symptoms

II. PRIMARY ACUPOINT NEURO-CIRCUIT ATLAS

ID	Point	Meridian	Region	Peripheral Nerves	Dermatome	Segment	Central Nodes	Output Circuit	Circuit Network	Evidence
PRION-001	GV20	Governing Vessel	Vertex	Greater Occipital	C2	C2	DMN, PFC, PCC	Global synchronization	Cortico-thalamic	B
PRION-002	GV24	Governing Vessel	Frontal scalp	Supraorbital nerve	CN V1	Cranial	Frontal Executive Network	Cognitive regulation	Fronto-limbic	B
PRION-003	EX-HN1 (Sishencong)	Extra	Vertex perimeter	Occipital-trigeminal convergence	C2	C2	DMN	Network stabilization	Connectomic	B
PRION-004	Yintang	Extra	Glabella	Supratrochlear nerve	CN V1	Cranial	Amygdala, ACC	Emotional regulation	Limbic	C
PRION-005	GV26	Governing Vessel	Philtrum	Infraorbital nerve	CN V2	Cranial	Reticular Activating System	Consciousness support	Brainstem-arousal	C
PRION-006	GB20	Gallbladder	Suboccipital	Greater Occipital	C2-C3	Cervical	Cerebellum, Brainstem	Vestibular regulation	Cerebello-brainstem	B
PRION-007	BL10	Bladder	Upper cervical	Cervical dorsal rami	C2-C3	Cervical	NTS, Medulla	Autonomic stabilization	Brainstem	C
PRION-008	DU16	Governing Vessel	Foramen magnum region	Suboccipital nerves	C1-C2	Cervical	Medulla	Respiratory-autonomic regulation	Brainstem	C
PRION-009	PC6	Pericardium	Forearm	Median nerve	C6-T1	Cervicothoracic	NTS, DMV	Cardiovagal modulation	Autonomic	A
PRION-010	HT7	Heart	Wrist	Ulnar nerve	C8-T1	Cervicothoracic	Limbic-autonomic nodes	Sleep-autonomic support	Limbic-autonomic	B
PRION-011	CV17	Conception Vessel	Sternum	Intercostal branches	T2-T5	Thoracic	Cardiopulmonary centers	Respiratory synchronization	Autonomic	C
PRION-012	ST36	Stomach	Leg	Deep Peroneal nerve	L4-L5	Lumbar	NTS, Vagal-adrenal pathway	Neuroimmune modulation	Neuroimmune	A
PRION-013	LI11	Large Intestine	Elbow	Radial nerve	C5-C6	Cervical	Hypothalamic-inflammatory circuits	Cytokine regulation	Neuroimmune	B
PRION-014	LI4	Large Intestine	Hand	Median-Radial overlap	C6-C7	Cervical	PAG, Insula	Analgesic regulation	Nociceptive	B
PRION-015	SP6	Spleen	Medial leg	Tibial nerve	L4-S2	Lumbosacral	Endocrine-autonomic systems	Metabolic regulation	Neuroendocrine	B
PRION-016	KI3	Kidney	Medial ankle	Tibial nerve	L4-S1	Lumbosacral	Hypothalamic integration	Fatigue-energy regulation	Neuroendocrine	C
PRION-017	LV3	Liver	Foot	Deep peroneal nerve	L5-S1	Lumbosacral	Limbic circuitry	Behavioral modulation	Limbic	B
PRION-018	GB34	Gallbladder	Lateral leg	Common peroneal nerve	L4-S1	Lumbosacral	Basal ganglia	Motor integration	Motor network	B
PRION-019	BL40	Bladder	Popliteal fossa	Tibial nerve	L5-S2	Lumbosacral	Motor circuits	Lower extremity regulation	Motor network	C
PRION-020	BL62	Bladder	Lateral ankle	Sural nerve	S1-S2	Sacral	Brainstem locomotor networks	Gait control	Locomotor	C
PRION-021	Anmian	Extra	Mastoid region	Great auricular nerve	C2-C3	Cervical	Thalamus, hypothalamus	Sleep regulation	Thalamocortical	C
PRION-022	Shenmen (Auricular)	Auricular	Ear	Auricular branch vagus nerve	CN X	Cranial	NTS	Parasympathetic activation	Vagal network	A
PRION-023	Brainstem (Auricular)	Auricular	Ear	Auricular vagus nerve	CN X	Cranial	Medullary nuclei	Brainstem regulation	Brainstem	A
PRION-024	Thalamus (Auricular)	Auricular	Ear	Auricular vagus nerve	CN X	Cranial	Thalamus	Sleep-connectomic support	Thalamocortical	A
PRION-025	Sympathetic (Auricular)	Auricular	Ear	Auricular vagus nerve	CN X	Cranial	Autonomic network	Sympathetic regulation	Autonomic	A

III. PRION SUBTYPE-SPECIFIC CIRCUIT MAPS

A. Sporadic Creutzfeldt-Jakob Disease (sCJD)

Primary Collapse:

Cortical ribboning
Basal ganglia degeneration
Global connectomic collapse

Priority Network:

GV20

GV24

Sishencong

GB20

PC6

ST36

B. Variant CJD (vCJD)

Primary Collapse:

Pulvinar degeneration
Limbic dysfunction
Psychiatric symptoms

Priority Network:

GV20

Yintang

HT7

LV3

PC6

Anmian

C. Fatal Familial Insomnia (FFI)

Primary Collapse:

Thalamic degeneration
Sleep architecture destruction
Autonomic instability

Priority Network:

Anmian

HT7

PC6

CV17

GV20

Auricular Thalamus

D. Gerstmann-Sträussler-Scheinker

Primary Collapse:

Cerebellar degeneration
Ataxia
Motor instability

Priority Network:

GB20

GB34

BL40

BL62

ST36

IV. THALAMOCORTICAL COLLAPSE PANEL

Functional Domain	Dominant Nodes	Acupuncture Mapping
Sleep Failure	Thalamus	HT7, Anmian, Auricular Thalamus
Consciousness Decline	Reticular System	GV26, GV20
Cognitive Collapse	PFC-DMN	GV20, GV24, Sishencong
Emotional Dysregulation	Amygdala	HT7, Yintang, LV3
Autonomic Dysfunction	NTS-DMV	PC6, CV17, Shenmen
Ataxia	Cerebellum	GB20, GB34, BL62

V. PRION CONNECTOMIC SEVERITY STRATIFICATION

Stage I

Early Connectomic Disruption

Characteristics:

Mild cognitive symptoms
Early sleep disturbance
Minimal autonomic dysfunction

Network:

GV20

HT7

PC6

ST36

Stage II

Moderate Connectomic Collapse

Characteristics:

Cognitive decline
Behavioral symptoms
Gait instability

Network:

GV20

GV24

Sishencong

GB20

PC6

HT7

Stage III

Severe Connectomic Collapse

Characteristics:

Severe dementia
Autonomic dysfunction
Loss of functional independence

Network:

GV20

PC6

CV17

Shenmen

Anmian

Supportive/Palliative Focus

Stage IV

Terminal Connectomic Failure

Characteristics:

Akinetic state
Brainstem dysfunction
Severe autonomic failure

Network:

PC6

CV17

Shenmen

Brainstem Auricular Point

Palliative Focus Only

VI. SCF BIOMARKER-INTEGRATED ACUPUNCTURE FORECASTING

Biomarker Pattern	SCF Fault	Network Selection
RT-QuIC Positive + Tau ↑	Prion propagation	GV20 + GV24
NfL ↑	Axonal degeneration	GV20 + GB20
GFAP ↑	Astrocytic collapse	ST36 + LI11
HRV ↓	Autonomic collapse	PC6 + CV17
Sleep architecture loss	Thalamic degeneration	HT7 + Anmian
DTI collapse	Connectomic fragmentation	GV20 + Sishencong
Behavioral dysregulation	Limbic degeneration	HT7 + LV3 + Yintang

VII. CLINICAL SAFETY NOTES

Prion diseases require:

Neurology supervision
Neurodegenerative disease expertise
Infection control precautions
Palliative medicine involvement
Supportive multidisciplinary care

This atlas is intended for:

Symptom modulation research
Connectomic modeling
Autonomic support investigation
Sleep and behavioral symptom management

It is not intended as a curative intervention framework.

MASTER REGISTRY INDEX

SCF-ECCA-PRION-ACU-0010 — Prion Encephalopathy Acupuncture Point Mapping Atlas
SCF-ECCA-PRION-BIO-0010 — Prion Encephalopathy Biomarker Panel
SCF-ECCA-PRION-CONNECTOME-0010 — Prion Connectomic Collapse Framework
SCF-ACU-NEURO-ATLAS-0001 — SCF Neural Mapping Schema
SCF-ECCA-0001 — Encephalopathy Connectomic Collapse Atlas
SCF-BIOMARKER-ENDPOINTS-0001 — SCF Biomarker Endpoint Validation Framework
SCF-PATH-PROT-0001 — SCF Pathophysiology Protocol
SCF-THALAMOCORTICAL-COLLAPSE-0010 — Thalamocortical Failure Reconstruction Framework
SCF-BRAINSTEM-AUTONOMIC-0010 — Brainstem Autonomic Failure Mapping Framework